| 持股明細(資料日期：2025/12/31) |
| 持股名稱 | 比例 |
| VERTEX PHARMACEUTICALS INC | 8.63% |
| GILEAD SCIENCES INC | 8.05% |
| AMGEN INC | 7.82% |
| REGENERON PHARMACEUTICALS INC | 6.89% |
| ALNYLAM PHARMACEUTICALS INC | 4.55% |
| INSMED INC | 3.23% |
| ARGENX SE ADR | 3.00% |
| NATERA INC | 2.65% |
| BIOGEN INC | 2.27% |
| BEONE MEDICINES AG | 1.94% |
| UNITED THERAPEUTICS CORP | 1.78% |
| ILLUMINA INC | 1.72% |
| INCYTE CORP | 1.69% |
| GENMABSPONSORED ADR | 1.34% |
| NEUROCRINE BIOSCIENCES INC | 1.21% |
| REVOLUTION MEDICINES INC | 1.16% |
| MEDPACE HOLDINGS INC | 1.12% |
| BRIDGEBIO PHARMA INC | 1.11% |
| IONIS PHARMACEUTICALS INC | 1.11% |
| MADRIGAL PHARMACEUTICALS INC | 1.06% |
| EXELIXIS INC | 1.00% |
| BIOMARIN PHARMACEUTICAL INC | 0.99% |
| MODERNA INC | 0.90% |
| AVIDITY BIOSCIENCES INC | 0.88% |
| ASCENDIS PHARMA ADR REPRESENTING | 0.87% |
| CHARLES RIVER LABORATORIES INTERNA | 0.86% |
| ROIVANT SCIENCES LTD | 0.83% |
| BIO TECHNE CORP | 0.80% |
| REPLIGEN CORP | 0.77% |
| ARROWHEAD PHARMACEUTICALS INC | 0.74% |
| HALOZYME THERAPEUTICS INC | 0.69% |
| CYTOKINETICS INC | 0.67% |
| AXSOME THERAPEUTICS INC | 0.67% |
| ABIVAX AMERICAN DEPOSITARY SHARES | 0.63% |
| PRAXIS PRECISION MEDICINES INC | 0.61% |
| RHYTHM PHARMACEUTICALS INC | 0.59% |
| BIONTECH SE ADR | 0.58% |
| KRYSTAL BIOTECH INC | 0.54% |
| TEMPUS AI INC CLASS A | 0.53% |
| PTC THERAPEUTICS INC | 0.52% |
| VAXCYTE INC | 0.52% |
| PROTAGONIST THERAPEUTICS INC | 0.45% |
| BRUKER CORP | 0.43% |
| NUVALENT INC CLASS A | 0.42% |
| CRISPR THERAPEUTICS AG | 0.42% |
| KYMERA THERAPEUTICS INC | 0.41% |
| ALKERMES | 0.40% |
| ACADIA PHARMACEUTICALS INC | 0.39% |
| COGENT BIOSCIENCES INC | 0.38% |
| AMICUS THERAPEUTICS INC | 0.38% |
| ADMA BIOLOGICS INC | 0.37% |
| CRINETICS PHARMACEUTICALS INC | 0.36% |
| STRUCTURE THERAPEUTICS ADR INC | 0.32% |
| TERNS PHARMACEUTICALS INC | 0.32% |
| APOGEE THERAPEUTICS INC | 0.32% |
| SCHOLAR ROCK HOLDING CORP | 0.31% |
| TRAVERE THERAPEUTICS INC | 0.30% |
| XENON PHARMACEUTICALS INC | 0.30% |
| MIRUM PHARMACEUTICALS INC | 0.29% |
| VERACYTE INC | 0.29% |
| TARSUS PHARMACEUTICALS INC | 0.28% |
| ARCUTIS BIOTHERAPEUTICS INC | 0.28% |
| CARIS LIFE SCIENCES INC | 0.27% |
| LEGEND BIOTECHADR REP CORP | 0.27% |
| IDEAYA BIOSCIENCES INC | 0.26% |
| GRAIL INC | 0.25% |
| ARCELLX INC | 0.25% |
| NEWAMSTERDAM PHARMA NV | 0.23% |
| APELLIS PHARMACEUTICALS INC | 0.23% |
| BEAM THERAPEUTICS INC | 0.22% |
| VERA THERAPEUTICS INC CLASS A | 0.22% |
| ADAPTIVE BIOTECHNOLOGIES CORP | 0.21% |
| DYNE THERAPEUTICS INC | 0.21% |
| WAVE LIFE SCIENCES LTD | 0.20% |
| SPYRE THERAPEUTICS INC | 0.19% |
| IMMUNOVANT INC | 0.19% |
| DENALI THERAPEUTICS INC | 0.19% |
| NUVATION BIO INC CLASS A | 0.19% |
| DISC MEDICINE INC | 0.19% |
| SAREPTA THERAPEUTICS INC | 0.19% |
| ULTRAGENYX PHARMACEUTICAL INC | 0.18% |
| MINERALYS THERAPEUTICS INC | 0.18% |
| CG ONCOLOGY INC | 0.18% |
| ZYMEWORKS INC | 0.17% |
| NURIX THERAPEUTICS INC | 0.17% |
| EDGEWISE THERAPEUTICS INC | 0.17% |
| AURINIA PHARMACEUTICALS INC | 0.17% |
| TWIST BIOSCIENCE CORP | 0.16% |
| 10X GENOMICS INC CLASS A | 0.16% |
| VERICEL CORP | 0.16% |
| SUMMIT THERAPEUTICS INC | 0.16% |
| DYNAVAX TECHNOLOGIES CORP | 0.16% |
| CENTESSA PHARMACEUTICALS AMERICAN | 0.16% |
| ARCUS BIOSCIENCES INC | 0.16% |
| SYNDAX PHARMACEUTICALS INC | 0.16% |
| RECURSION PHARMACEUTICALS INC CLAS | 0.15% |
| MANNKIND CORP | 0.15% |
| FORTREA HOLDINGS INC | 0.14% |
| OLEMA PHARMACEUTICALS INC | 0.14% |
| KODIAK SCIENCES INC | 0.14% |
| BIOCRYST PHARMACEUTICALS INC | 0.13% |
| AGIOS PHARMACEUTICALS INC | 0.13% |
| ZAI LABORATORY ADR REPRESENTING LT | 0.13% |
| STOKE THERAPEUTICS INC | 0.13% |
| UNIQURE NV | 0.12% |
| IMMUNOCORE HOLDINGS ADR PLC | 0.12% |
| BLK CSH FND TREASURY SL AGENCY | 0.12% |
| NOVOCURE LTD | 0.11% |
| ORUKA THERAPEUTICS INC | 0.11% |
| MIND MEDICINE SUBORDINATE VOTING I | 0.11% |
| BIOHAVEN LTD | 0.11% |
| ANAPTYSBIO INC | 0.11% |
| MESOBLAST ADR REPRESENTINGLTD | 0.11% |
| GALAPAGOS ADR REPRESENTING NV | 0.11% |
| TAYSHA GENE THERAPIES INC | 0.11% |
| GRIFOLS ADR REPRESENTING ONE NON-V | 0.10% |
| ATAI BECKLEY N V NV | 0.10% |
| CASTLE BIOSCIENCES INC | 0.10% |
| RELAY THERAPEUTICS INC | 0.10% |
| AMYLYX PHARMACEUTICALS INC | 0.10% |
| MAZE THERAPEUTICS INC | 0.10% |
| TREVI THERAPEUTICS INC | 0.09% |
| XENCOR INC | 0.09% |
| SIONNA THERAPEUTICS INC | 0.09% |
| CUREVAC NV | 0.09% |
| STEVANATO GROUP | 0.09% |
| NOVAVAX INC | 0.09% |
| INTELLIA THERAPEUTICS INC | 0.09% |
| TYRA BIOSCIENCES INC | 0.08% |
| IOVANCE BIOTHERAPEUTICS INC | 0.08% |
| UROGEN PHARMA LTD | 0.08% |
| THERAVANCE BIOPHARMA INC | 0.08% |
| KURA ONCOLOGY INC | 0.08% |
| CAREDX INC | 0.08% |
| RAPPORT THERAPEUTICS INC | 0.08% |
| MBX BIOSCIENCES INC | 0.07% |
| INHIBRX BIOSCIENCES INC | 0.07% |
| GERON CORP | 0.07% |
| ZENAS BIOPHARMA INC | 0.07% |
| ABCELLERA BIOLOGICS INC | 0.07% |
| TANGO THERAPEUTICS INC | 0.07% |
| RIGEL PHARMACEUTICALS INC | 0.07% |
| SEPTERNA INC | 0.07% |
| JANUX THERAPEUTICS INC | 0.07% |
| PHARVARIS N V NV | 0.06% |
| ARBUTUS BIOPHARMA CORP | 0.06% |
| ARS PHARMACEUTICALS INC | 0.06% |
| UPSTREAM BIO INC | 0.06% |
| REPLIMUNE GROUP INC | 0.06% |
| PHATHOM PHARMACEUTICALS INC | 0.06% |
| DAY ONE BIOPHARMACEUTICALS INC | 0.06% |
| SANA BIOTECHNOLOGY INC | 0.06% |
| ENLIVEN THERAPEUTICS INC | 0.06% |
| REGENXBIO INC | 0.06% |
| MONTE ROSA THERAPEUTICS INC | 0.06% |
| FULCRUM THERAPEUTICS INC | 0.06% |
| IMMUNITYBIO INC | 0.06% |
| ARVINAS INC | 0.06% |
| ASTRIA THERAPEUTICS INC | 0.06% |
| EMERGENT BIOSOLUTIONS INC | 0.06% |
| PRECIGEN INC | 0.06% |
| ANNEXON INC | 0.05% |
| SAVARA INC | 0.05% |
| KALVISTA PHARMACEUTICALS INC | 0.05% |
| RAPT THERAPEUTICS INC | 0.05% |
| LEXEO THERAPEUTICS INC | 0.05% |
| ALUMIS INC | 0.05% |
| ERASCA INC | 0.05% |
| CYTEK BIOSCIENCES INC | 0.05% |
| KEROS THERAPEUTICS INC | 0.05% |
| VENTYX BIOSCIENCES INC | 0.05% |
| GOSSAMER BIO INC | 0.05% |
| GH RESEARCH PLC | 0.05% |
| VIR BIOTECHNOLOGY INC | 0.05% |
| ALVOTECH SA | 0.05% |
| MYRIAD GENETICS INC | 0.05% |
| CYTOMX THERAPEUTICS INC | 0.05% |
| BRIDGEBIO ONCOLOGY THERAPEUTICS IN | 0.05% |
| BICARA THERAPEUTICS INC | 0.05% |
| IRONWOOD PHARMA INC CLASS A | 0.05% |
| FULGENT GENETICS INC | 0.05% |
| ARRIVENT BIOPHARMA INC | 0.05% |
| PACIFIC BIOSCIENCES OF CALIFORNIA | 0.04% |
| ZEVRA THERAPEUTICS INC | 0.04% |
| COMPASS PATHWAYS ADR PLC | 0.04% |
| OPKO HEALTH INC | 0.04% |
| ALTO NEUROSCIENCE INC | 0.04% |
| VANDA PHARMACEUTICALS INC | 0.04% |
| ABSCI CORP | 0.04% |
| STANDARD BIOTOOLS INC | 0.04% |
| MEIRAGTX HOLDINGS PLC | 0.04% |
| LENZ THERAPEUTICS INC | 0.04% |
| CORVUS PHARMACEUTICALS INC | 0.04% |
| ORIC PHARMACEUTICALS INC | 0.04% |
| ENANTA PHARMACEUTICALS INC | 0.04% |
| PERSONALIS INC | 0.04% |
| PROTHENA PLC | 0.04% |
| CULLINAN THERAPEUTICS INC | 0.04% |
| PEPGEN INC | 0.03% |
| 4D MOLECULAR THERAPEUTICS INC | 0.03% |
| ALTIMMUNE INC | 0.03% |
| AUTOLUS THERAPEUTICS ADR PLC | 0.03% |
| LINEAGE CELL THERAPEUTICS INC | 0.03% |
| GINKGO BIOWORKS HOLDINGS INC CLASS | 0.03% |
| ADC THERAPEUTICS SA | 0.03% |
| ROCKET PHARMACEUTICALS INC | 0.03% |
| MARAVAI LIFESCIENCES HOLDINGS INC | 0.03% |
| SOLID BIOSCIENCES INC | 0.03% |
| PRIME MEDICINE INC | 0.03% |
| IMMUTEP ADS REPRESENTINGLTD | 0.03% |
| IMMUNEERING CORP CLASS A | 0.03% |
| ANAVEX LIFE SCIENCES CORP | 0.03% |
| NOVABRIDGE BIOSCIENCES ADR | 0.03% |
| BIOAGE LABS INC | 0.03% |
| DESIGN THERAPEUTICS INC | 0.03% |
| CONTINEUM THERAPEUTICS INC CLASS A | 0.03% |
| ACLARIS THERAPEUTICS INC | 0.02% |
| NEUROGENE INC | 0.02% |
| KYVERNA THERAPEUTICS INC | 0.02% |
| AURA BIOSCIENCES INC | 0.02% |
| BICYCLE THERAPEUTICS ADR PLC | 0.02% |
| QUANTERIX CORP | 0.02% |
| CANDEL THERAPEUTICS INC | 0.02% |
| CELLECTIS ADR REPRESENTING SA | 0.02% |
| ATEA PHARMACEUTICALS INC | 0.02% |
| ALLOGENE THERAPEUTICS INC | 0.02% |
| ENTRADA THERAPEUTICS INC | 0.02% |
| LYELL IMMUNOPHARMA INC | 0.02% |
| TECTONIC THERAPEUTIC INC | 0.02% |
| OMNIAB INC | 0.02% |
| EDITAS MEDICINE INC | 0.02% |
| QUANTUM SI INC CLASS A | 0.02% |
| CABALETTA BIO INC | 0.02% |
| AC IMMUNE SA | 0.02% |
| VOYAGER THERAPEUTICS INC | 0.02% |
| LARIMAR THERAPEUTICS INC | 0.02% |
| PERSPECTIVE THERAPEUTICS INC | 0.02% |
| AARDVARK THERAPEUTICS INC | 0.01% |
| ARCTURUS THERAPEUTICS HOLDINGS INC | 0.01% |
| SAGIMET BIOSCIENCES INC SERIES A | 0.01% |
| HUMACYTE INC | 0.01% |
| C4 THERAPEUTICS INC | 0.01% |
| FOGHORN THERAPEUTICS INC | 0.01% |
| TENAYA THERAPEUTICS INC | 0.01% |
| CODEXIS INC | 0.01% |
| CARIBOU BIOSCIENCES INC | 0.01% |
| JYONG BIOTECH LTD | 0.01% |